In our opinion, a few issues need to be taken into account both in interpreting the Padova results and in considering the pros and cons of a take-home naloxone trial. First, it decreases a user’s tolerance to opioids, which means that if someone relapses and goes back to using the same amount of opioids before treatment, they have a heightened risk of experiencing overdose and death. home naloxone as a practice was mentioned but not advised (3). Naloxone is a medication approved by the Food and Drug Administration (FDA) designed to rapidly reverse opioid overdose. Nearly 60% of those deaths (22,134) involved pharmaceutical drugs. Naloxone, the other active ingredient in Suboxone, is an opioid antagonist that blocks the effects of other opioid drugs by competing for space among the brain’s opioid receptors. Nonprescription naloxone: pros and cons. In 2010, drug overdose deaths increased for the 11th consecutive year, causing 38,329 deaths in the United States. Once administered, it immediately counteracts the overdose and revives the person by blocking the effects of an overdose. Some significant cons are associated with naltrexone. With the potential to save a human life from opiate overdose, reversing the effects of opioids, Naloxone is legitimately considered a “miracle” drug. A recent study claims naloxone access may unintentionally increase opioid abuse through two channels: (1) reducing the risk of death per use, thereby making riskier opioid use more appealing, and (2) saving the lives of active drug users, who survive to continue abusing opioids. Still, naloxone hydrochloride (Narcan) has a list of pros and cons to keep in mind. Due to Suboxone’s mechanism of action, it can be used as an effective replacement for more harmful opioid drugs during addiction treatment therapy. NALOXONE PROS AND CONS. It is an opioid antagonist—meaning that it binds to opioid receptors and can reverse and block the effects of other opioids, such as such as heroin, morphine, and oxycodone. Naloxone has saved thousands of lives in Ohio, according to the state Department of Mental Health & Addiction Services: “Approximately 74,000 naloxone administrations occurred from 2003 to 2012. Some signs and symptoms of an opioid emergency are breathing problems (which can range from slow or shallow breathing to no breathing), extreme sleepiness, slow heartbeat, or not being able to respond. A good proportion of … EXPERT ANALYSIS FROM THE AAAP ANNUAL MEETING AVENTURA, FLA. -- Clinicians interested in providing naloxone for their patients at risk for an opioid overdose should consider the pros and cons of the different formulations, addiction medicine specialists say. Many people wonder what the difference between naltrexone and naloxone is since the drugs work in essentially the same way. The number of naloxone administrations per year grew every year from 4,010 in … The main difference between naloxone and naltrexone is the half-life of each medication. This presentation is provided for pharmacists and providers who wish to learn more about factors that increase an individuals' risk of opioid overdose, identify signs and symptoms of opioid overdose, and understand the pros and cons of different naloxone formulations. DOI: 10.1331/JAPhA.2014.14048 Corpus ID: 28785167. The Cons. What Are The Pros And Cons Of Naloxone Vs Naltrexone? In the case of opiate overdose, minutes count. Narcan, also known as naloxone, is a nasal spray that is the only treatment with an FDA approval for overdose. Naloxone (Narcan) Pros. Naloxone Vs Naltrexone: A Brief Overview. Cons. 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